Chemoselective fluorination of 2-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-ones using DAST
نویسندگان
چکیده
منابع مشابه
Design and synthesis of some thiazolidin-4-ones based on (7-hydroxy-2-oxo-2H-chromen-4-yl) acetic acid.
(7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid methyl ester(1) upon reaction with ethyl bromoacetate furnishes (7-ethoxycarbonylmethoxy-2-oxo-2H-chromen-4-yl)-acetic acid methylester (2), which on treatment with 100% hydrazine hydrate yields (7-hydrazinocarbonylmethoxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide (3). The condensation of compound 3 with different aromatic aldehydes afforded a se...
متن کاملA novel NHC-catalyzed transformation of 2H-chromene-3-carboxaldehydes to 3-methyl-2H-chromen-2-ones.
An unexpected transformation of 2H-chromene-3-carboxaldehydes to coumarin derivatives, mediated by NHC, is reported.
متن کاملAntioxidant activity of some (7-hydroxy-2-oxo-2H-chromen-4-yl) acetic acid derivatives
A series of coumarin Schiff bases (7-(arylidenehydrazinocarbonylmethoxy)-2-oxo-2H-chromen-4-yl]acetic acid arylidenehydrazide) (4a-k) and N-(2-aryl-4-oxothiazolidin-3-yl)-2-{[4-(2-aryl-4-oxothiazolidin-3-yl)carbamoylmethyl]-2-oxo2H-chromen-7-yloxy}-acetamides (5a-k) were synthesized and evaluated for their antioxidant activity (scavenging of 1,1diphenyl-2-picryhydrazyl radical and phosphomolybd...
متن کامل2-Oxo-2H-chromen-4-yl propionate
In the title compound, C12H10O4, the atoms of the 2-oxo-2H-chromene ring system and the non-H atoms of the 4-substituent all lie on a crystallographic mirror plane. The mol-ecular structure exhibits an intra-molecular C-H⋯O hydrogen bond, which generates an S(6) ring. In the crystal, mol-ecules form R 3 (2)(12) trimeric units via C-H⋯O inter-actions which propagate into layers parallel to the a...
متن کامل3-Benzyl-2H-chromen-2-one
The title compound, C(16)H(12)O(2), is a coumarin which was isolated from stones of the Chinese traditional medicine Clausena lansium. The pyrone ring is almost planar, with a mean deviation of 0.0135 (4) Å. The benzene ring (A) of the benzopyrone unit forms dihedral angles of 1.82 (5) and 72.86 (2)° with the pyrone ring and the substituent benzene ring, respectively. The crystal structure is s...
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ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 2011
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2011.04.070